Investigation into Potential Interactions between the Unique Transcription Factor WhiB1 and Rv2699c in Mycobacterium tuberculosis
While WhiB1 is known to be an essential monomeric transcription factor highly implicated in the Mycobacterium tuberculosis (Mtb) stress response, the mechanism of transcriptional regulation by WhiB1 remains elusive. The research investigated in this study hopes to advance knowledge underlying the novel regulatory mechanism of WhiB1 in Mtb for broad applications in the epidemic of tuberculosis. In particular, we investigate the potential structure and function of Rv2699c in this role. An in-depth understanding of the pathogen’s ability to persist in hosts and Mtb’s ability to persist through its complication regulatory system will prelude the development of exciting new treatments in fight the Mtb epidemic.
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