NL3 Lab Tour

Kelcey Buck Author

05/15/2020 Added

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Virtual tour of the facilities used by Yingying Wang's Neuroimaging for Language, Literacy and Learning (NL3) Lab at the Center for Brain, Biology and Behavior (CB3).

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[00:00:03.370]Hi, my name is YingYing Wang.
[00:00:06.220]I'm currently assistant professor
[00:00:08.800]at University of Nebraska Lincoln,
[00:00:12.520]at the Department of Special Education
[00:00:14.410]and Communication Disorder.
[00:00:16.440]And I'm the director of Neuroimaging
[00:00:19.040]for Language, Literacy and Learning.
[00:00:22.060]So, here we are, here is the MRI simulator room.
[00:00:27.070]And this is one of the system
[00:00:29.380]I use a lot for my one of the project,
[00:00:32.280]is to study children who are learning to read
[00:00:37.240]and how actually the brain changes over time.
[00:00:41.160]And then especially not just in typical children.
[00:00:45.240]And then also in children who are deaf or hard of hearing.
[00:00:48.460]Why we need this simulator is because for younger children,
[00:00:52.030]especially for my interest group,
[00:00:54.630]they are younger than six years old.
[00:00:57.370]So for them to actually adapt to the environment
[00:01:00.140]and to know what the true MRI room will be
[00:01:02.950]and then what the noise is and then what the table is.
[00:01:05.600]And then also we make it a child friendly,
[00:01:07.700]we tell them this is a jungle.
[00:01:09.410]So they will be playing a game in the real MRI room.
[00:01:12.540]So give them a half an hour
[00:01:13.940]before the real session actually increasing
[00:01:16.130]a chance for them to be successful.
[00:01:18.750]My lab is trying to use state of the art,
[00:01:22.880]neuroimaging techniques to understand
[00:01:25.630]biological mechanism of certain behaviors,
[00:01:29.300]of brain plasticity.
[00:01:33.120]Brain plasticity can be due
[00:01:35.830]to experience or maybe some insult
[00:01:39.270]to the brain, traumatic brain injury or stroke
[00:01:41.930]causing the brain to change what happened in the brain.
[00:01:45.390]The neural basis is what I really focus on in our lab.
[00:01:49.250]So currently, we have two main project one we call it BDR,
[00:01:53.920]which stands for Brain Development of Reading.
[00:01:56.590]So we study children.
[00:01:58.250]They are, how their brain changes
[00:02:00.380]over the period that when they learn to read.
[00:02:02.880]Another project, we call BACIC.
[00:02:05.230]So it is Bring Activation of Cochlear Implant Candidates.
[00:02:09.880]So for those individuals,
[00:02:11.500]they are going to get a cochlear implant.
[00:02:13.820]And then we will ask them
[00:02:15.030]to come to our lab to get brain imaging data.
[00:02:18.410]And then also follow them longitudinally.
[00:02:20.810]The goal is we want to understand anything
[00:02:24.500]in the brain, can that help us
[00:02:26.290]to predict their surgical outcomes?
[00:02:29.280]Mostly focus on their speech
[00:02:30.930]perception ability after surgery.
[00:02:33.390]And then, if you don't know about cochlear implant,
[00:02:36.530]it's a device you actually implant
[00:02:38.590]in your inner ear to help those individuals
[00:02:41.660]who has severe to profound hearing loss
[00:02:44.110]to regain the ability to hear.
[00:02:46.170]So this process is not like we get a glasses
[00:02:49.100]and then you have the glasses you can see right away.
[00:02:52.080]Our brains have to adapt to this new device
[00:02:54.850]and to learn, to establish new pathway,
[00:02:58.776]to land a new sensory.
[00:03:00.450]Because the cochlear implant
[00:03:01.860]only gave us a degraded sound signal.
[00:03:04.570]It's not the traditional sound
[00:03:07.160]we hear as a typical hearing person.
[00:03:09.880]So this is the actual EMI system,
[00:03:12.490]and the three Tesla Siemens Skyra.
[00:03:15.700]And this is where actually,
[00:03:18.070]this is the machine my lab use a lot
[00:03:20.020]to collect functional MRI data
[00:03:23.430]and located a Center
[00:03:25.180]for Brain Biology and Behavior, CB3.
[00:03:28.150]So CB3 offers a unique opportunity
[00:03:32.090]for faculties across campus
[00:03:34.510]to collaborate with interdisciplinary projects.
[00:03:38.340]Here you are in the FNIS lab.
[00:03:40.660]So FNIS stands for Functional Near Infrared Spectroscopy.
[00:03:44.670]So if you look at here,
[00:03:46.110]we have those light sensors
[00:03:47.840]and the red is the source and then the blue is the detector.
[00:03:51.180]And then what happens is
[00:03:53.160]when we actually show you a paradigm
[00:03:54.910]to the participants, their brain activity,
[00:03:57.750]we're causing the deoxygenated hemoglobin
[00:04:02.350]actual hemoglobin content changes
[00:04:04.230]and which can be detected by these light sources.
[00:04:07.540]So that's how we can detect the function of the brain.
[00:04:10.800]And then we use this one
[00:04:12.080]to study individuals with cochlear implant
[00:04:14.830]because when someone had a cochlear implant,
[00:04:17.650]they can't go into the MRI scan anymore.
[00:04:20.120]So this device is actually compatible
[00:04:22.870]with the cochlear implant users.
[00:04:25.010]And they're safer for them
[00:04:27.480]to get their imaging, their brain function,
[00:04:30.940]brain imaging scan.

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NL3 Lab Tour

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